Ohio State Buckeyes vs. Indiana Hoosiers Betting Odds, College Football Pick

The last time Indiana beat Ohio State on a football field, none of the current players on either team were alive. But the Hoosiers, who have lost 20 times in a row to the Buckeyes, are 4-0 against the spread over the last four meetings. Indiana takes its shot at the defending national champs Saturday afternoon in Bloomington.

Point spread: Buckeyes opened as 17.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

College football pick, via Odds Shark computer: 43.9-24.1 Buckeyes

Why the Ohio State Buckeyes can cover the spread

OSU is off to a 4-0 start to this season after beating Western Michigan last week 38-12. The Buckeyes led 14-0, gave up a long touchdown pass for a score, then scored the next 17 points of the game to take control. Ohio State piled up 511 yards of offense, 223 on the ground, although ultimately it couldn’t cover as heavy home chalk.

So far this season, the Buckeyes’ best performance came in the toughest spot: a 42-24 victory at Virginia Tech. But the beginning of the Big Ten season might provide an emotional kick as OSU shoots for a second consecutive conference championship and the berth in the College Football Playoff that will probably come with it.

Finally, Ohio State is 14-0 SU and 9-5 ATS on the road under head coach Urban Meyer.

Why the Indiana Hoosiers can cover the spread

IU is also off to a 4-0 start to this season, and 3-1 ATS, after winning at Wake…

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