June 15, 2026

College football odds, picks, lines for Week 12: Proven computer model loving Ohio State, Virginia Tech

The Week 12 college football odds board is full of games that will have a huge impact on conference title races. A win this weekend goes a long way in cementing Pittsburgh’s place in the ACC title game, and the Panthers are favored by 6.5, up half-a-point from the opening line, at Wake Forest. No. 10 Ohio State (-14.5), meanwhile, needs a win at Maryland to stay in the Big Ten East conversation. And No. 15 Texas (-3) vs. No. 16 Iowa State and No. 9 West Virginia (-4.5) at Oklahoma State will have major implications in the wide-open Big 12. With so much at stake as the season winds down and college football odds and lines on the move, be sure to check out the top Week 12 college football picks and predictions from SportsLine’s proven computer model. The SportsLine Projection Model simulates every FBS college football game 10,000…

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