June 15, 2026

College football odds, picks, lines for Week 12: Proven computer model loving Arizona State and Ohio State

With conference championship week and the bowl season looming, the Week 12 college football schedule is all about survival for the teams left in contention for a national championship. No. 3 Notre Dame is a 10.5-point favorite against No. 12 Syracuse at Yankee Stadium in the Shamrock Series, while No. 11 UCF is a seven-point favorite at home over No. 19 Cincinnati in the latest Week 12 college football odds. Notre Dame needs to make a statement to shore up its resume, while UCF needs a statement win to have any shot of earning consideration. With so much on the line and college football odds and spreads moving all week, check out what the advanced computer model at SportsLine has to say before locking in any Week 12 college football picks and predictions. The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed…

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