June 27, 2026

Ohio State vs. Michigan State preview, prediction: Week 6 college football picks

A pair of Big Ten rivals meet up as No. 3 Ohio State goes on the road for the first time this season to square off against Michigan State in college football’s Week 6 action on Saturday. Ohio State is perfect through five games, including a 2-0 mark in Big Ten play, outscoring Wisconsin and Rutgers, 101-31. Sparty is 2-3 on the year and yet to win in conference after two tries, losing three straight overall since a trip to Washington before dropping two decisions against Minnesota and Maryland. Here’s what you need to know about Saturday’s matchup. Ohio State vs. Michigan State preview, prediction © Provided by CFB-HQ on FanNation Week 6 college football picks: Ohio State vs. Michigan State How to watch When: Sat., Oct. 8 Time: 4 p.m. Eastern TV: ABC network Stream: fuboTV (Start your free trial) More college football on SI: College football scores | College…

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