June 14, 2026

Ohio State vs. Iowa prediction, odds, line: 2022 Week 8 college football picks, best bets from proven model

USATSI The Iowa Hawkeyes (3-3) and the No. 2 Ohio State Buckeyes (6-0) match up in a Big Ten contest on Saturday afternoon. Ohio State and Heisman Trophy hopeful C.J. Stroud roll into this game on a six-game winning streak, outlasting Michigan State 49-20 last week. On the flip side, Iowa is currently on a two-game skid. On Oct. 8, the Hawkeyes fell to Illinois 9-6. Iowa is 3-3 against the spread, while Ohio State is 3-2-1 ATS in 2022. Kickoff from Ohio Stadium in Columbus is set for noon ET. Caesars Sportsbook lists the Buckeyes as 30-point favorites in the latest Iowa vs. Ohio State odds, while the over/under for total points is 50. Before making any Ohio State vs. Iowa picks, be sure to check out the college football predictions and betting advice from SportsLine’s proven model. The SportsLine Projection Model simulates every FBS college football game 10,000…

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