June 19, 2026

Ohio State vs. Northwestern prediction, odds: 2022 Week 10 college football picks, best bets by proven model

USATSI The No. 2-ranked Ohio State Buckeyes will be on alert for a letdown spot Saturday when they travel to face the struggling Northwestern Wildcats in a Big Ten matchup. Last week, the Buckeyes (8-0, 5-0) trailed early in the fourth quarter against No. 13-ranked Penn State, but surged late for a 44-31 victory to remain undefeated. Now they turn their focus to the struggling Wildcats (1-7, 1-4) , who fell 33-13 to Iowa last week and are searching for their first win since a 31-28 Week 1 triumph over Nebraska. Kickoff is set for noon ET from Northwestern’s Ryan Field. Caesars Sportsbook lists the Buckeyes as 38-point favorites and the over/under for total points scored is 55.5 in the latest Ohio State vs. Northwestern odds. Before locking in any Northwestern vs. Ohio State picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer…

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