June 26, 2026

Ohio State vs. Indiana prediction, odds: 2022 Week 11 college football picks, best bets from proven model

USATSI After struggling in a win last week, the second-ranked Ohio State Buckeyes look to get their offense right when they take on the Indiana Hoosiers in a key Big Ten Conference East Division matchup on Saturday. It had been seven weeks since the last time the Buckeyes (9-0, 6-0) had been held to as few as 21 points. Ohio State’s lowest point total during that stretch was 44 in a win two weeks ago at Penn State. The Hoosiers (3-6, 1-5) have lost six in a row after a 3-0 start, which included a 23-20 win over Big Ten West-leading Illinois 23-20 in the season opener. Kickoff from Ohio Stadium in Columbus, Ohio, is set for noon ET. Ohio State leads the all-time series 76-12-5, and has won the last 26 meetings. The Buckeyes are 40-point favorites in the latest Indiana vs. Ohio State odds from Caesars Sportsbook, while…

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