June 24, 2026

Ohio State vs. Indiana prediction, odds: 2022 Week 11 college football picks, best bets from computer model

USATSI The second-ranked Ohio State Buckeyes look to win their 27th consecutive game over the Indiana Hoosiers when they meet in a key Big Ten Conference East Division matchup on Saturday. The Buckeyes (9-0, 6-0), one of four remaining unbeaten teams, are coming off a 21-7 win at Northwestern last week. The Hoosiers (3-6, 1-5), who have lost 13 consecutive games in October and November, are coming off a 45-14 loss to Penn State. This will be the first time Indiana has been a 40-point underdog since at least 1995. Kickoff from Ohio Stadium in Columbus, Ohio, is set for noon ET. Ohio State is averaging 45.8 points per game this season, best in the nation, while Indiana averages 23.3, 11th-best in the Big Ten and 100th in the country. The Buckeyes are favored by 40 points in the latest Indiana vs. Ohio State odds from Caesars Sportsbook, while the…

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