June 23, 2026

Ohio State vs. Michigan prediction, odds: 2022 Week 13 college football picks, best bets from proven model

USATSI The Big Ten East Division title and a spot in the Big Ten Championship Game are on the line on Saturday when the third-ranked Michigan Wolverines battle the second-ranked Ohio State Buckeyes in a rivalry matchup simply referred to as The Game. The Wolverines (11-0, 8-0), who are 3-0 on the road this season, are an impressive 536-216-18 all-time in Big Ten play. The Buckeyes (11-0, 8-0), who are 7-0 at home in 2022, have dominated their opposition, winning all of their games by no fewer than 11 points. This will be the 12th time the teams have met with both ranked in the Associated Press Top 5, the most of any rivalry. Ohio State leads these games in wins 7-3-1. Kickoff from Ohio Stadium in Columbus, Ohio, is set for noon ET. Michigan leads the all-time series 59-52-2, although Ohio State holds a 28-27-2 edge in games played…

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