July 6, 2026

College football odds, picks, predictions for Week 3: Proven computer model loving Oklahoma, Ohio State


Conference play highlights a significant portion of the Week 3 college football schedule, as many top-tier teams move away from cupcake opponents to more heated, dangerous rivalries. Top-ranked Clemson has had trouble on the road at Syracuse in the past, and the Tigers are giving 27 to the Orange on Saturday in the latest college football odds. No. 2 Alabama, similarly, lost in upset fashion at South Carolina in 2010 the last time they were in Columbia and are favored by 26 over the Gamecocks, one of the largest college football spreads of the week. Meanwhile, Kentucky hosts No. 9 Florida (-9) in a rematch of the electrifying Wildcats upset a season ago. And who could overlook the Cy-Hawk Trophy matchup between Iowa (-1.5) and Iowa State at a jam-packed Jack Trice Stadium that features one of the tightest college football lines. And for the late-night crowd, Texas (-30.5) gets…

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