June 24, 2026

Ohio State vs. Penn State odds, line: 2021 college football picks, Week 9 predictions from model on 26-11 run

Getty Images A pair of ranked Big Ten teams will face off this weekend with No. 5 Ohio State hosting No. 20 Penn State at Ohio Stadium on Saturday. The Buckeyes haven’t lost since falling short against No. 7 Oregon in Week 2, while the Nittany Lions are looking to rebound from a stunning loss to Illinois last weekend.  Kickoff is set for 7:30 p.m. ET. The Buckeyes are 18.5-point favorites in the latest Ohio State vs. Penn State odds from Caesars Sportsbook, while the over-under for total points scored is 61. Before locking in any Penn State vs. Ohio State picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer model. The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players…

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