June 27, 2026

Duke vs. Ohio State odds, line, spread: 2021 college basketball picks, Nov. 30 predictions from proven model

Getty Images The Duke Blue Devils arrive in Columbus, Ohio as the nation’s No. 1 team, but they’ll face a stern test on Tuesday against the Ohio State Buckeyes. The matchup, part of 2021 ACC/Big Ten Challenge week, is the Blue Devils’ first nonconference road game in almost two years, and the Buckeyes have been hard to gauge so far. The Blue Devils (7-0) come in off a huge 84-81 victory against then-No. 1 Gonzaga on Friday night, while the Buckeyes (4-2) lost 71-68 to current No. 14 Florida last Wednesday. OSU has depth and talent but is trying to fit the pieces together after some key personnel losses. Tipoff is set for 9:30 p.m. ET at Value City Arena. The Blue Devils are three-point favorites in the latest Duke vs. Ohio State odds from Caesars Sportsbook, while the over-under for total points scored is set at 147. Before making…

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